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Therefore, folate is critical for rapidly dividing cells, including erythroblasts (red blood cell precursors in the bone marrow) and developing foetal tissue

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Cytochrome c in turn binds to Apaf-1 and triggers the assembly of the apoptosome (Yuan and Akey, 2013), which interacts with pro-caspase-9 to produce its cleavage into caspase-9 that activates a caspase cascade leading to apoptosis by caspases-3/7 (Friedman and Nunnari, 2014)